Puja starting her television career with Kahaani Hamaaray Mahaabhaarat Ki, Bose was seen in the romantic show Tujh Sang Preet Lagai Sajna, in which she played the role of a simple Punjabi girl, Vrinda.
She has also acted in a Telugu film titled Veedu Theda. She made her debut in the film Macho Mustanaa, with Hiran Chatterjee (formerly called Macho Mustafaa, but the title was changed due to objections from Muslim clerics regarding the use of the word “Mustafaa” She won a role in Raja Chanda’s film Challenge 2, starring Dev Adhikari and Sujit Mondal’s film Rocky, starring Mahaakshay Chakraborty. Another unconfirmed movie is Diwana Holo Mon, opposite Hiran Chatterjee.
Bose participated in Jhalak Dikhhla Jaa (season 7), where she was credited as Puja Bose. Her choreographer was Rajit Dev, who is the chief choreographer to Vaibhavi Merchant.